Lipocalin-type prostaglandin D synthase produces prostaglandin D2 involved in regulation of physiological sleep.

A urine biomarker for severe obstructive sleep apnoea patients: lipocalin-type prostaglandin D synthase.

Lipocalin-type prostaglandin D synthase (L-PGDS), which is responsible for the biosynthesis of prostaglandin D2, has been reported to have a close connection with cardiovascular disease and sleep regulation. This study aimed to test the hypothesis that the L-PGDS level is a useful marker to identify patients with obstructive sleep apnoea. 64 subjects were enrolled in this prospective study. Uri...

Molecular Mechanism of Sleep-wake Regulation

Prostaglandin (PG) D2 is the most potent endogenous sleep-promoting substance thus far reported and its sleep-inducing mechanism is the best characterized at the molecular level. PGD2 is produced by lipocalin-type PGD synthase (L-PGDS) localized in the leptomeninges, choroid plexus, and oligodendrocytes in the brain and is secreted into the cerebrospinal fl uid as a sleep hormone. PGD2 stimulat...

Lipocalin-type Prostaglandin D2 Synthase Regulates Glial Cell Migration and Morphology through Marcks: Prostaglandin D2-independent Effects

Lipocalin-type prostaglandin D2 synthase reduces glucagon secretion in alpha TC-1 clone 6 cells via the DP1 receptor

Diabetes is associated with disturbances in the normal levels of both insulin and glucagon, both of which play critical roles in the regulation of glycemia. Recent studies have found lipocalin-type prostaglandin D2 synthase (l-PGDS) to be an emerging target involved in the pathogenesis of type-2 diabetes. This study focused on the effect of l-PGDS on glucagon secretion from cultured pancreatic ...

Reduction of lipocalin-type prostaglandin D synthase in the preoptic area of female mice mimics estradiol effects on arousal and sex behavior.

In female rodents, sleep and activity levels fluctuate over the estrous cycle. When estradiol (E2) levels are highest, sleep is reduced whereas locomotion is increased. The preoptic area (POA) is a key site for estrogenic regulation of these functions. However, molecular mechanisms by which E2 acts to reduce sleep and increase activity are unclear. Recently, we demonstrated a twofold reduction ...